Yeah, I guess I can. It's just simpler in Paint is all. Much easier... Plus I tend to use it to recolor sprites on a sprite sheet en masse without having to use the fill bucket on all of them. However, Photoshop seems to be able to do color replacement so I won't worry about that...
And I made a wonderful screwup with my VMware Windows, I used Filemon to pick up what Dlls Paint was trying to get to. Somewhere along my moving of them into OS X I must have wound up doing something to User32.dll and now the VM won't start up. I won't ask for help on fixing this, I think I found where to do it... but I won't bother with it for a while. I think I shouldn't be doing that kind of crap anyway.
Short version: I'm an idiot.