http://en.wikipedia.org/wiki/Randy_Pausch - For details.
In short, he's a accomplished professor that is dying, he'll pass on soon due to pancreatic cancer.
So he did what is called the "Last Lecture" a lecture where you compose what you'd pass on to everyone if you were about to die. In his case, it's true.
Some people don't like this kind of stuff, but I think he really passed on a lot of good advice/wisdom/whatever you want to call it.